Dr. Molly Wilson-Murphy discusses flu season from a child neurology perspective, including current topics and controversies surrounding vaccination and the impact of declining vaccination rates, as well as rare but serious complications including influenza-associated acute necrotizing encephalopathy. Tips include early identification and treatment, acute and long-term complications, and counseling strategies for families in both inpatient and outpatient settings including primary prevention (vaccination) as well as outcomes and prognosis.